Abstract
In rabbits with hypertension changes in the basic amino nitrogen, and the monoamino nitrogen fractions of the blood proteins have been described by Bernhard and Drekter 1 . The investigation has been extended to include a study of the blood of normal children and the blood of children and adults with hypertension.
Fifteen normal children between the ages of 17 months and 12 years served as controls. In this group the basic amino nitrogen content of the whole blood varied between 370 and 620 mg. per 100 cc., and the monoamino nitrogen between 1200 and 1990 mg. per 100 cc. Considered in per cent of the total nitrogen after hydrolysis the basic amino nitrogen of the whole blood varied between 19.4% and 27.0%, while the monoamino nitrogen varied between 62 and 79%. The basic amino nitrogen in the red cells varied between 280 and 490 mg. per 100 cc., and the monoamino nitrogen between 900 and 1650 mg. per 100 cc. The percentage of the total nitrogen after hydrolysis ranges between 17.8% and 27.8% for the basic amino nitrogen. The basic amino nitrogen of the serum protein is fairly constant from 100-150 mg. per 100 cc. and the monoamino nitrogen is between 300 and 420 mg. per 100 cc. The variation in per cent of total nitrogen after hydrolysis varies between 20.0% and 27.8% for the basic amino nitrogen, and between 55.5 and 77% for the monoamino nitrogen.
The blood proteins were analyzed in 4 cases of hypertension. One case, a child, 4 years of age, had a blood pressure of 170/86 mm. The other 3 cases were adults, with blood pressures of 170/95, 230/124, and 210/125 respectively. In all of these cases the blood urea and creatinine were within normal limits.
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