Abstract
Wickman 1 , 2 dwelt at some length upon the lesions of the central nervous system associated with acute poliomyelitis, and as a result of the accuracy of his original observations his descriptions of the changes encountered have been little altered in subsequent years. Wickman noted that the vascular lesions of acute poliomyelitis were more marked in the veins than in the arteries, and that the frequently encountered round cell infiltration was situated in the lymph channels of the vessel wall. It was also recognized, however, that the lymphocytic infiltration was often of sufficient intensity to extend beyond the adventitial limits of the vessels into the surrounding tissues. Flexner and Amoss 3 pointed out that in cases of acute poliomyelitis induced by intravenous administration of virus the vascular lesions were more extensive than in instances of infection by other routes.
The lesion described below was encountered in the meningeal vessels of a Macacus cynomolgus which developed acute poliomyelitis after having been fed with virus-infected milk. The material used was a 10% milk suspension of recently glycerinated brain and spinal cord from monkeys which had succumbed to typical poliomyelitis. Six daily feedings of 30 cc. were administered by mouth with the aid of a medicine dropper, the milk being fed slowly so that the monkey could swallow it easily.
Symptoms were first apparent 11 days after the last feeding, at which time the animal moved about slowly and showed obvious weakness of the left leg.
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