Specificity of Pathogenic Infections of the Kidney

Abstract

Conclusion

(1) Colon bacilli and staphylococci are commonly present in the urine of so-called normal dogs. (2) Organisms are very easily demonstrated in the glomerular capillaries, Bowman's capsule, and the tubules within the first 36 hours after injection of the renal artery with 24-hour cultures. (3) Areas in the kidney are found, following injection of the renal artery, in which there is complete necrosis of the tubules, but normal glomeruli and interstitial tissue are present showing that the tubules derive their main blood supply from the efferent vessel of the glomerulus. (4) The irijection of one renal artery in this investigation produced no lesions in the contralateral kidney. (5) Staplzylococcw aureus produced cortical abscesses after 22 hours, whereas the colon bacillus seldom produced abscesses, but resulted in degeneration of the distal tubules when from 4 to 6 agar slants were introduced into the renal artery. (6) Acute glomerulo-nephritis can be produced by injections of Staplzylococcus aureus and colon bacillus into the renal artery. (7) Chronic interstitial nephritis can be produced within a period of 3 weeks, especially following injection of colon bacilli.