Abstract
Folin 1 states that “Glycuresis is independent of the level of blood sugar and is not normally obtained from the ingestion of pure glucose.”
The opposite view is expressed by Benedict in the following: 2 “We note at once that in every instance there is a definite general form to the curve of the sugar elimination following the ingestion of the sugar. The general form of this curve is a rise in the middle and a fall at both ends,” and “ … offers convincing evidence that the experimental factor (glucose ingestion) was responsible for an increased urinary sugar excretion in these experiments.”
The experiments reported were designed to compare glycuresis during short intervals, with frequent values for blood sugar for comparison.
Thirty-six experiments were performed on 25 human subjects. We have found that the moderate rises in the blood sugar level after the ingestion of either pure glucose or a mixed meal are accompanied by parallel increases in the amount of urinary sugar excreted per hour. With the ingestion of 50 gm. of pure glucose in 20% solution we have observed an increase in urinary sugar from 14 mg. per hour to 26 mg. and 60 mg., with a return to 16 mg. and 15 mg. per hour, and this curve of increased sugar elimination follows closely the fluctuation in the level of the blood sugar, which in this case went from 80 mg. to 85 and 89 and then returned to 83 and finally 79 mg. per 100 cc. of blood, all sub-threshold values.
Similar results were obtained after mixed meals.
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