Abstract
The experimental formation of bone in the urinary tract was first observed by Sacerdotti and Frattin 1 in rabbits where the renal vessels had been ligated. This has also been observed by Poscharissky, 2 Maximow, 3 Liek 4 and Asami and Dock. 5 The bone occurs in thin lamellae immediately beneath the mucosa of the pelvis. Bone does not occur if the ureter also is ligated. Pearce, 6 following excision of the lower pole (approximately one-half) of the kidney with suture of the defect, observed bone formation in 6 of 19 dogs. Bone developed in connection with epithelial buds of the pelvic mucosa. He says “for this peculiar localization there is no explanation.” In application of phenol (95%) and an electric current of high frequency to the renal pelvis of dogs, I have observed bone formation in 3 of 5 dogs. Strauss 7 observed bone formation beneath the regenerated ureteral mucosa, lining the lumen of the graft. Neuhof 8 observed formation of bone in a fascial patch sutured in a defect of the bladder in 18 dogs. Invariably confined to the fascia replacing the defect and situated in the surface of the graft bordering on the urine. This observation was confirmed by Phemister 9 in the dog, but not in the bladder of the rabbit or sheep. The explanations for the development of bone in the ureter or bladder were based on a metaplasia due to some factor in the urine.
In my experiments, auto-transplantation was done throughout.
Experiment I: 3 dogs. Both ureters transplanted to the skin, the bladder was emptied and fascia from the sheath of the rectus abdominis muscle was transplanted to fill a circular operative defect 3 cm. in diameter in the dome of the bladder.
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