Abstract
Summary
Sodium thiosulphate shows no deleterious action on the trypanocidal activity of the salvarsan groups when the two drugs are given simultaneously. These results are corroborated by clinical observations of other investigators. Sodium thiosulphate plays an important part in the rate of excretion and also the clinical symptoms following an intoxication due to arsenic in (a) inorganic state, (b) pentavalent organic state, and (c) the organic trivalent arsenicals.
Clinical study showed that when the injections of thiosulphate were stopped and the arsenic output in the urine dropped down to about 0.003 to 0.004 mg., the eruption on the head, hands and feet and the peculiar lichenoid eruption on the back, chest, arms and legs regularly became worse. With the renewed administration of the thiosulphate, and when the arsenic output came up to about one decigram of arsenic for each 100 gm. of moist specimen, the eruption regularly improved.
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