Abstract
The stomach, intestines and spleen of dogs were removed without interfering with the hepatic circulation. This was done by connecting the portal vein with the abdominal vena cava by means of a transfusion cannula, the return circulation from the hind quarters replacing the normal portal circulation. Dogs thus partially eviscerated give typical anaphylactic reactions on intravenous injection with specific foreign protein, the arterial blood pressure falling to a third, even to a quarter, of the normal arterial pressure within two minutes.
The intestine, therefore, is not the dominant site of the extra-hepatic vascular reactions in canine anaphylaxis, as currently assumed.
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