Abstract
It has been claimed by some 1 that injections of secretin stimulated the blood forming tissue. After injections of an acid extract of intestinal mucous membrane (secretin) there is a sharp rise in the blood count. The time required for the rise and return to normal is about three hours.
Using stained smears and supravital staining (brilliant cresyl blue) as criteria of new cell formation, it is found that there is no increase in the percentage of reticulocytes and no evidence of unusual marrow activity in the stained smears. Therefore, the rise in count must be due to an escape of plasma and not to increased cell formation.
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