Clinical observations on the use of the anti-diabetic substance

Abstract

Conclusion

1. Potent preparations of the internal secretion of the pancreas can be made by aqueous acid extraction and perfusion.

2. These preparations were made non-toxic and non-irritant for hypodermatic and intravenous administration.

3. The hyperglycemia can be markedly reduced and the glycosuria and acetonuria can be made to disappear by means of these preparations.

4. The clinical condition of patients can be markedly improved, e. g., the thirst and polyuria diminished, edema removed, weight gained and mental sluggishness caused to disappear.

5. The carbohydrate tolerance is increased commensurate with the amounts of extracts employed.

6. Dessicated pancreatic extracts taken in capsule form by stomach have thus far not proved to be effective in reducing blood or urinary sugar.

7. Patients in complete coma can be brought back to a rational condition, their acidosis controlled and the non-protein nitrogen and creatinine lowered to a normal level.

8. Thus far no definite evidence has been obtained to show that the carbohydrate tolerance of a diabetic patient is permanently raised by temporary extract treatment.