Abstract
The absence of glycosuria and the high sugar tolerance in myxoedematous individuals led us to undertake the experiments cited in this brief report.
Dog No. 100, male, weight 14 kilo., partial pancreatectomy performed January 12, 1921. Urine positive for sugar the following day. It persisted in amounts of from 2 to 3 per cent. until January 19, when both inferior thyroid arteries were ligated. Glycosuria continued until January 26, 1921, when complete thyroidectomy was done, sparing the parathyroids. Urine became negative for sugar on the following day and continued so. On February 5, 1921, with blood sugar 95 mgms. an additional 3.4 gms. of pancreatic tissue was removed with no change in the urinary findings. On February 9, blood sugar was 86 mgms. On this day 150 gms. glucose were introduced by the stomach tube. Tests for urinary sugar remained negative. On May 9, rest of the pancreas, amounting to 10 gms. was removed. Urine continued negative for sugar until May 14, when intestines prolapsed through wound, followed by death next day. Autopsy revealed complete absence of pancreatic tissue. His blood sugar was 66 mgms. before the last pancreatectomy and his weight 15.9 kilo.
Dog No. 106, male, weight 7.52 kilo., complete pancreatectomy on March 2, 1921; weight of removed pancreas being 18.2 gms. Urine positive for sugar, beginning day following operation in amounts varying between 5 and 6 per cent. On March 5, both superior and inferior thyroid arteries were ligated. He continued to have sugar in decreasing amounts until March 8, when the urine became negative for sugar. Urine continued to be negative for sugar until March 19, when distemper developed followed by death the next day.
Blood sugar findings were as follows:
Autopsy revealed lobular pneumonia involving all the lobes. Complete absence of pancreatic tissue.
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