Responsiveness of Cerebral Osmoreceptors in the Anesthetized Dog

Abstract

Abstract

Experiments were carried out to determine if, in the anesthetized dog undergoing a water diuresis, selective elevation of cerebral osmolality induced an antidiuresis. Bilateral intracarotid infusion of hypertonic sodium chloride in an amount previously shown to increase jugular plasma osmolality by 3% was associated with a significant decline in C _H2O. The same volume of hypertonic sodium chloride infused intravenously did not alter C _H2O significantly. These experiments do not support the view that anesthesia blocks the response of cerebral osmoreceptors.