Abstract
Abstract
The mechanism for the transport of urate was examined using the gastric mucosa of the frog. After short circuiting the tissue to zero potential, both the unidirectional serosal to mucosal and the mucosal to serosal flux of urate were found to be a direct function of the initial concentration of urate. The serosal to mucosal permeability coefficient averaged 6.5 ± 0.8 × 10−10 cm/sec; a value not different from the mucosal to serosal permeability coefficient of 7.7 ± 0.8 × 10−10 cm/sec. These results suggest that urate passes through the gastric mucosa by passive diffusion only. When compared to the small intestine and proximal tubule of the rat the permeability coefficient for urate is significantly lower. Though the gastrointestinal tract is a potential route for the elimination of uric acid, the stomach does not appear to play a major role.
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