Abstract
Abstract
Dietary administration of theophylline (2.5 g/kg of food) induced a spontaneous appetite for NaCl solution in female rats given a choice between water and 0.25 M NaCl solution to drink. The appetite was accompanied by a reduction in preference threshold to one-third that of controls as determined by the two-bottle choice technique. Dietary administration of 3-isobutyl-1-methylxanthine (IBMX) (2.50 g/kg of food) was also accompanied by a spontaneous appetite for 0.25 M NaCl solution when female rats were allowed to choose between it and distilled water to drink. The mechanism by which theophylline and IBMX affect the appetite for NaCl solutions is unknown but could be related to their phosphodiesterase inhibitory activity and/or to their ability to block adenosine receptors.
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