Abstract
Abstract
Administration of 3-methylcholanthrene to C3H/HeJ and C57BL/6J mice at four dose levels over a 1:125 range resulted in a practically equal tumor response in both strains at all dose levels. Liisa Prehn and E. M. Lawler (Science 204: 309-310, 1979), using a different method of carcinogen administration, found a reversal of tumor susceptibility when varying the dose of carcinogen, a phenomenon not observed by us. Our study suggests that Prehn and Lawler's results may have been influenced, at least in part, by the practice of the latter authors to exclude data of substantial numbers of tumor-free mice from the evaluation.
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