Abstract
Abstract
Direct measurement of glomerular capillary pressure, without removing cortical tissue from the micropuncture site, was the objective of this study. The measurement was accomplished by random micropuncture below the kidney surface with simultaneous recording of pressure at the tip of the micropuncture pipet. Glomerular capillary pressure was identified by a stable, pulsatile tracing synchronous with renal artery pressure or blood flow. In 50 micropunctures in 16 dogs glomerular capillary pressure was 56 ± 3 mm Hg. Mean arterial pressure averaged 127 ± 3 mm Hg. The conclusion that pulsatile pressure recorded during random micropuncture resulted from impalement of glomerular capillaries is supported by experiments in Munich Wistar rats. In 14 rats there was no significant difference between pressure measured either in superficial glomeruli (46 ± 1 mm Hg) or during random micropuncture (47 ± 1 mm Hg).
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