Abstract
Abstract
A comparison was made of the effects of testosterone, 5β-dihydrotestosterone, and etiocholanediol on in vitro erythroid colony formation (CFU-E) in mouse bone marrow cultures. Dose-response curves with the three steroids in the presence of 0.2 unit Ep revealed that etiocholanediol at 10-11 - M significantly enhanced CFU-E erythroid colony formation compared to 5β-DHT at the same doses. Testosterone at 10-8 M significantly enhanced colony formation compared to 5β-DHT at the same dose. It is postulated from these studies that the bone marrow may convert testosterone to 5β-DHT and the more erythropoietically active etiocholanediol which may be the active metabolite of testosterone stimulating in vivo erythropoiesis.
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