Direct Action of Prostaglandins on Renin Release from Rat Renal Cortical Slices 1

Abstract

Abstract

Various prostaglandins (PG's) and their precursors were superfused to rat renal cortical slices to evaluate their renin-stimulating actions. PGE₂, PGI₂, PGF_2α, PGE₁, and PGD₂ stimulated renin release significantly. However, PGA₂ and 6-keto-PGF_1α did not stimulate renin release. The prostaglandin precursors, arachidonic acid and the endoperoxide analog, U-44069, also stimulated the release of renin. Since the renin-stimulating action of arachidonic acid was blocked by indomethacin, arachidonic acid-mediated renin release was caused by its conversion to the endoperoxides or to PG's. Our studies indicate that PG's may play an important role in the control of renin release. From our results, PGE₂ produced a significant increase in renin release at lower concentrations than any other PG's tested whereas PGI₂ caused the greatest percentage increase in renin release.