Abstract
Abstract
The changes in the phospholipid content of healing rat fracture callus were shown to resemble those occurring during endochondral ossification. Specifically, the calcium—acidic phospholipid—phosphate complexes (Ca-PL-PO4) which have been associated with the onset of mineralization in other tissues, are most abundant in the Day 11 fracture callus (19% of total lipid) where mineral is accumulating most actively. The Ca-PL-PO4 content then gradually decreases to the value observed for metaphyseal and diaphyseal bone (6% of total lipid). This study provides further proof that the Ca-PL-PO4 complexes are associated with the early stages of mineralization, and demonstrates another manner in which fracture healing in the rat resembles endochondral ossification.
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