Abstract
Abstract
A specific antibody to human renin was produced employing a pure human renal renin as antigen. This antibody inhibited the activity of human renal renin but did not inhibit the activities of hog renal renin, rat renal renin, and mouse submaxillary gland renin. Using this antibody an immunoaffinity column was constructed. The gel-bound antibody was used to demonstrate its capability to neutralize inactive prorenin in human plasma as well as active plasma renin, indicating that inactive plasma renin contains structures common to renal renin.
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