Abstract
Summary
Two series of experiments were conducted to determine the effect of sympathetic nerve stimulation on hypocapnic airway constriction in the isolated left lower lobe (LLL) of the dog anesthetized with sodium pentobarbital. In the first series, hypocapnic airway constriction was produced by lobar artery occlusion. The bronchodilator effect of sympathetic stimulation on hypocapnic airway constriction was compared to the bronchodilator effect of sympathetic stimulation on the constrictor effects of vagal nerve stimulation. In the second series, the LLL was isolated and pump perfused. Hypocapnic airway constriction was produced by reducing the inspired CO2 from 5 to 0% in O2. The increase in lobar artery pressure caused by sympathetic stimulation was used as an index of the effectiveness of sympathetic stimulation to the LLL. In neither series did sympathetic stimulation have a significant effect on hypocapnic airway constriction.
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