Abstract
Summary
Cultured P388 cells derived from vincristine-resistant cell populations developed in vivo (P388/VCR) retain their resistance to vincristine, although the degree of resistance of the P388/VCR cell populations appears to be a function of concentration and time of exposure. The P388/VCR cell population is sensitive to 4′-demethylepipodophyllotoxin ethylidene-β - D - glucoside (VP 16-213) but a degree of cross-resistance to VP 16-213 can be demonstrated. The degree of cross-resistance to VP 16-213 also appears to be a function of concentration and time of exposure.
We thank Dr. H. E. Skipper, Dr. F. M. Schabel, Jr., and Dr. R. W. Brockman for their helpful discussions and encouragement; Mr. John A. Burdeshaw for statistical analysis of the data; Dr. W. R. Laster and Mrs. Mary Trader for providing the leukemia P388 and vincristine-resistant P388 tumors; and Mrs. Carol S. Eldridge for excellent technical assistance.
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