Abstract
Summary
The experimental agent, mixidine fumarate, was studied in isolated perfused working rat hearts for effects on mechanical function and energy production. Mixidine had a potent negative chronotropic effect in this preparation. This in turn leads to decreased ventricular power development. The depression in mechanical function, however, was absent in mixidine treated hearts electrically paced at rates comparable to those of control hearts. Furthermore, mixidine produced no detectable changes in the myocardial energy producing pathways. From these studies it appears that mixidine is a specific chronotropic agent.
The technical assistance of Diane Ubele and Gretna Rodgers is gratefully acknowledged.
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