Mechanisms of Glucose-Induced Hyperemia in the Jejunum 1

Abstract

Summary

The present study compared the effects of placement of three glucose analogs into the jejunal lumen, with or without bile, on local blood flow, oxygen consumption, and glucose absorption. Both glucose and 3-O-methyl glucose were absorbed and increased local blood flow when placed into the lumen, 2-deoxy glucose was not absorbed and did not alter local blood flow. Glucose increased but 3-O-methyl glucose did not alter oxygen consumption and the former produced a greater hyperemia than the latter. The study thus suggests that the hyperemic effect of glucose in the jejunal lumen is, at least in part, related to glucose absorption and an increase in oxidative metabolism. Of the three glucoses, only the vascular effect of glucose was influenced by bile. Although the underlying mechanisms of this effect of bile are unknown, the study suggests that the mechanisms require structure specificity.