Abstract
Summary
The activity of nuclear envelope nucleoside triphosphatase, an enzyme implicated to be involved in nucleocytoplasmic translocation of mRNA, was investigated in the livers of rats that received a single tube-feeding of tryptophan. Tryptophan administered to fasted rats or to rats pretreated with puromycin or actinomycin D caused significant increases in the activity of Mg2+-dependent nucleoside triphosphatase in the hepatic nuclear envelopes over that in controls. Concomitant with this rapid (10 min) increase in the enzyme activity, there was more release of RNA from isolated nuclei of livers of tryptophan-treated rats than from those of control rats.
Get full access to this article
View all access options for this article.