Abstract
Summary
Concordance of polymorphic enzyme phenotypes in various comparisons of human normal and malignant cells in vitro and in vivo establishes isozyme stability after change to the malignant state and after long-term tissue culture. Such enzymes, therefore, can be used with considerable confidence to individually distinguish human tumor cell lines. The stability validates the use of phenotype frequency data obtained from surveys of normal human populations in the analysis of data on human tumor cell lines.
We gratefully acknowledge the collaboration of Dr. Francis E. Sharkey and the Department of Pathology, Memorial Hospital, New York, for providing tissue specimens.
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