Abstract
Summary
African green monkeys consuming a diet containing 0.62 mg cholesterol/Cal and 40% of calories as fat were characterized for whole-body cholesterol metabolism after control (sham) or portacaval shunt operations. Whole-body cholesterol metabolism was studied by three different methods: sterol balance analysis, serum cholesterol turnover analysis, and feeding radiolabeled cholesterol until a serum cholesterol isotopic steady state was reached. We found no difference between control and portacaval shunt animals for the following characteristics: serum cholesterol concentration, excretion of neutral steroids or bile acids, cholesterol absorption or synthesis, and kinetic parameters of serum cholesterol turnover. We have concluded that portacaval shunt in African green monkeys fed a diet containing high fat and a moderate amount of cholesterol had no effect on whole-body cholesterol metabolism.
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