Abstract
Summary
Diffusion chamber granulopoiesis was studied in irradiated mice injected with anti-CSF serum. Total cellularity, proliferative and nonproliferative granulocytes were markedly suppressed by 4 days injection of antiserum. Moreover, granulocytic stem cells were markedly decreased. This suggests that CSF is necessary for maintaining the integrity of the granulocytic stem cell and for inducing differentiating granulopoiesis.
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