Abstract
Summary
Semi-rigid analogs of trans α-and β-rotameric conformations of dopamine and epinine were studied for their β-adrenergic activity on isolated rabbit aortic strips. 2-Amino-6,7-dihydroxytetrahydronaphthalene and its N-methyl derivative (analogous to the trans β-rotamer of dopamine) were 30- to 50-fold more potent than 2-amino-5,6-dihydrox-ytetrahydronaphthalene and its N-methyl derivatives, respectively, indicating that the trans β-rotamer, rather than the trans α-rotamer, is the preferred conformation for action on the α-adrenergic receptors.
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