Effects of Glucose on Glucagon Secretion by the Anolian Splenic Pancrease

Abstract

Summary

Glucagon secretion from splenic pancreata of Anolis carolinensis was not significantly increased by a 56% decrease in the concentration of glucose (1 mg/ml). When the glucose concentration was reduced to 0.5 mg/ml, a significant increase in glucagon release was observed. Arginine (10 m^M) did not significantly alter glucagon secretion. The pattern of glucagon secretion under stimulatory conditions shows a rapid onset and long duration. A concentration of glucose of 6 mg/ml failed to significantly decrease glucagon release. The results demonstrate the utility of the anolian splenic pancreas for exploring the regulation and dynamics of glucagon secretion.