Abstract
Summary
The injection of both viable and sonified nonviable preparations of M. arthritidis, M. pulmonis, and A. laidlawii into mice suppressed the interferon response of the animals to challenge with Newcastle disease virus (NDV). The inhibitory effect was dependent upon the numbers of organisms injected. The suppression of the interferon response was first apparent 14 hr postinjection and reached a maximum 1 and 3 days postinjection. High doses of organisms produced an inhibitory effect through 6 days. The mycoplasma component responsible for induction of hyporeac-tivity appeared to reside in the membrane fraction of the organisms. Heat treatment of mycoplasma preparations abolished the effect except at very high inocula.
Get full access to this article
View all access options for this article.