Abstract
Summary
Experiments were performed to examine the effect of estrogen administration on D-[1-14C]glucosamine uptake of rat trachea. Ovariectomized 125-g rats were given 25 μg of 17 β-estradiol daily for 8 days and sacrificed on the 9th day. Treated animals had a 20% increase/3 hr in uptake of radioactivity into acid-insoluble material of trachea. There was no change in aminosugar pool sizes. It was concluded that estrogen can cause changes in rat tracheal epithelium consistent with increased glycoprotein synthesis.
This study was supported in part by grants from the American Lung Association and the Council for Tobacco Research.
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