Immunogenicity of Two Naturally Occurring Solid-Phase Enamel Proteins

Abstract

Summary

An antiserum to native, solid-phase, insoluble enamel proteins from New Zealand white rabbits was raised in the same strain of animal. The ability of the antiserum to bind enamel proteins was demonstrated by fluorescence and radioimmu-noelectrophoretic techniques. The data were interpreted to suggestthat enamel proteins are sequestered from immune surveillance during early development, resulting in subsequently induced autoantibody production.

This research was supported by Grants DE-00095, DE-02848, and DE-03513 from the National Institutes of Health, and by a grant from the California Dental Association.