Abstract
Summary
The cholesterol synthesis was studied in germfree and conventional rats by assaying the HMG CoA (3-hydroxy-3-methylglutaryl CoA) reductase activity in the liver microsomal fraction. Germfree rats had a decreased activity (21.7 ± 3.8 pmole/ mg of protein/min) compared with conventional rats (50.5 ± 2.9). The results are discussed in relation to present knowledge of cholesterol metabolism in the two types of animals.
This work was supported by grants from the Swedish Medical Research Council (16X-206) and from Loo and Hans Osterman's Stiftelse.
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