Abstract
Summary
A number of anti-inflammatory agents were tested for their effect on the chemotaxis responsiveness and on the spontaneous motility of neutrophils obtained from rabbit and rat peritoneal exudates and human blood. The majority of these agents, both steroidal and nonsteroidal, inhibited the chemotactic responsiveness of neutrophils obtained from all three sources to a bacterial chemotactic factor. The effective steroidal anti-inflammatory agents tested inhibited both chemotaxis and spontaneous motility, whereas the nonsteroidal agents, with the exception of phenylbutazone, inhibited only chemotaxis and were without effect on motility.
We thank Mr. Henry Showell in the laboratory of Dr. Elmer Becker at the University of Connecticut Health Center for providing us with the butanol extract of E. coli culture filtrates. We also appreciate the work of Miss Kathy Walmsley and Mrs. Barbara Cerne in typing this manuscript.
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