Plasma Volumes and Entrapment of Plasma in Tissues of Normal and Insulin-Immunized Guinea Pigs 1

Abstract

Summary

Relative to body weight, the plasma volumes of 60 normal guinea pigs fell from 5.2 to 3.7 ml/100 g body wt as body weight increased from about 600 to 1200 g. Lower values reported by others are attributed to differences in methodology. Slightly higher plasma volumes were found in 37 insulin-immunized guinea pigs. After exsanguination at the time of death, trapped plasma accounted for 10 to 20% of the weights of the livers, kidneys, and spleens, more being trapped when death occurred before exsanguination could be effected.