Abstract
Summary
Compared to rats fed a high sugar diet, consumption of a high protein diet caused an enlargement of the kidneys, the increase being more pronounced at 5° than at 20°. High protein intake enhanced activities of renal glucose-6-phosphatase, fructose-1,6-diphosphatase, phosphoenol-pyruvate carboxykinase, glutamic dehydrogenase, and of the urea cycle enzymes. However, the activities of the gluconeogenic enzymes were higher at 5° than at 20°. In contrast, enzymatic activity was not changed in cold-exposed animals fed the high sugar diet. Since cold exposure stimulates food intake, it appears that enhanced renal gluconeogenesis observed in this study is substrate-induced rather than induced by cold per se.
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