Amantadine Decreases d-Amphetamine Stimulation and Increases d-Amphetamine Anorexia in Mice

Abstract

Summary

Amantadine hydrochloride (Symmetrel), an antiviral, antiparkinson agent that is most frequently used clinically at oral doses of 2 to 3 mg/kg, significantly decreased d-amphetamine-induced CNS stimulation (motor activity) and simultaneously increased d-amphetamine-induced anorexia (milk intake) in mice. Amantadine did this at oral doses of 2.5 and 5 mg/kg, which alone had no effect on either motor activity or milk intake.

We thank E. S. Dehorty, J. S. Gardner, and D. E. McCall for excellent technical assistance.