Plasma Prostaglandin F 2α and 15-Keto-F 2α Concentrations During Splanchnic Artery Occlusion Shock 1

Abstract

Summary

Arterial plasma concentrations of PGF_2α and 15-keto-PGF_2α were determined in sham shock and splanchnic artery occlusion shock dogs. Arterial PGF_2α concentrations (expressed as percentage of control) increased significantly in the SAO group when compared to the sham group during postrelease sampling periods. Similarly, 15-keto-PGF_2α, a major metabolite of PGF_2α also increased significantly in arterial blood in SAO shock. Comparison of 15-keto-PGF_2α and PGF_2α at each sampling period suggest that the efficiency of 15-hydroxyprostaglandin dehydrogenase is not impaired during SAO shock in the dog. However, the ability of the kidney and other organs to remove 15-keto-PGF_2αfrom the circulation during SAO shock does appear to be significantly reduced.

Although the changes in circulating concentrations of PGF_2α are significant, the role of the increased prostaglandin is not clearly understood. We found no basis for any toxic effect of the PGF_2α nor of any beneficial action. Others, however, have found exogenous PGF_2α to improve survival in circulatory shock (17).

The authors are grateful to Drs. J. Brian Smith and M. Silver for the anti-PGF_2α antibody used in this study. We are also grateful to Dr. John Pike of the Upjohn Company for a generous supply of prostaglandin. Indomethacin was supplied by Dr. Alexander Scriabine, Merck Institute for Therapeutic Research, West Point, Pa.