Abstract
Summary
Levels of serum opsonin for neutrophilic granulocytes were measured in dogs made neutropenic by cyclophosphamide administration. Heat-labile opsonin became elevated within 24 hr following cyclophosphamide (P < 0.005) and remained elevated over the 4-5 day period of observation (P < 0.005). In contrast, heat stable opsonin was not significantly effected. Bone marrow suppression by X-ray and busulfan also caused serum opsonin levels to increase. Changes in the levels of IgG, C3, and total hemolytic complement during the course of bone marrow suppression did not correlate with the granulocyte opsonin levels. These findings suggest that serum granulocyte opsonin levels respond to bone marrow suppression and may provide an improved environment for the function of transfused granulocytes.
We appreciate the help of Mr. Vincent Yakulis who performed the IgG and C3 assays and Mrs. Lilia Kizlai-tis who determined the hemolytic complement levels. The cyclophosphamide was generously supplied by the Mead-Johnson Laboratories, Evansville, Ind.
Get full access to this article
View all access options for this article.