Abstract
The subcutaneous injection of 0.06 to 0.08 gm. tyramin into normal individuals usually produces the following circulatory changes:
The systolic blood pressure increases markedly.
The diastolic blood pressure increases to a much less extent.
The pulse pressure is therefore increased.
The volume pulse in the arm becomes larger.
The heart rate is usually slowed.
The T wave in the electrocardiogram becomes notably larger with no constant change in the other waves. This alteration is most constant and is usually most marked in Lead II.
The changes in blood pressure and in the volume pulse in the arm indicate that the systolic output from the heart is increased. The changes in the electrocardiogram suggest those described by Rothberger and Winterberg after stimulating the right stellate (accelerator) ganglion.
Where epinephrin produces marked circulatory effects after subcutaneous injection these appear to be of a similar nature to those produced by tyramin. But tyramin is more constant in its action and it rarely causes the muscular tremor and apprehension that so frequently follows a large epinephrin injection.
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