Abstract
About fifteen years ago Herter and his coworkers reported that painting the pancreas with adrenalin causes a considerable glycosuria and they even assumed that the pronounced nature of glycosuria following intraperitoneal injections appears to be mainly attributable to the readiness with which the injected adrenalin comes in contact with the pancreas. Vosburgh and Richards reported later that the painting of the pancreas with adrenalin produces considerable hyperglycemia. To our knowledge the validity of these unusual statements was not confirmed or even tested since their publication. We have carried out recently a long series of experiments in which the hyperglycemia and glycosuria were studied after painting the pancreas. In the main we could not confirm these claims, but we wish however to mention here only one striking result. In eight experiments in which the pancreas was so isolated from the peritoneum that none of the adrenalin could enter the peritoneal cavity, the hyperglycemia as well as the glycosuria produced by the painting was insignificant, surely not more than would have occurred if the adrenalin had been given subcutaneously or painted on some part of the peritoneum.
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