Abstract
Summary
The accumulation of neutral amino acids was studied in cultivated human skin fibroblasts. Transport was blocked by sulfhydryl binding agents, but proceeded without inhibition in the presence of metabolic blocking agents. Both sodium dependent and sodium independent components of neutral amino acid accumulation were found. The sodium dependent component preferentially transports short chain amino acids, while the sodium independent system transports long chain amino acids. These components operate simultaneously and with overlap of substrate specificity. Both may function as parts of a single neutral amino acid transport system.
These studies were supported by Grants from The National Institutes of Health No. HD 04252 and The National Foundation—March of Dimes. Carol W. Booth is the recipient of The National Foundation— March of Dimes Fellowship in memory of David Y-Y. Hsia. Henry L. Nadler is the Irene Heinz Given and John La Porte Given Research Professor of Pediatrics.
Get full access to this article
View all access options for this article.