Abstract
Summary
Histidine decarboxylase activity was studied in the rat at various times following exposure to trauma. The enzyme activity in the lung increased 15 min after exposure to trauma, reached a peak at 4 hr, and returned to normal by 10 hr. In the spleen, the activity increased at four hr and returned to normal by 10 hr. No changes in the activity were found in the plasma. These results support the concept that in shock induced histamine is formed locally and may contribute to the changes in the microcirculation.
Get full access to this article
View all access options for this article.