Abstract
Summary
During exposure of rats to an intermittent electric shock PRA increased initially by about 500%. After 1-2 hr the PRA response decreased and after 8-24 hr PRA was no longer different from that of control-rats. Plasma corticosterone concentration stayed elevated during the whole 24 hr period.
Following hypophysectomy the increase of PRA was not inhibited and occurred also after 8 hr. Both dexamethasone and propranolol blocked completely the initial rise in PRA. Phentolamine potentiated the response.
These results suggest that stress-induced release of renin is mediated via β-adrenergic receptors and that endogenous corticosteroids modify this response.
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