Abstract
Summary
An investigation is reported on the effects of phenoxybenzamine and propranolol on the catecholamine-stimulated short-circuited current (Isc) of isolated frog skin. Phenoxybenzamine and propranolol inhibited the increase in Isc produced by both norepinephrine (NE) and isopropyl-arterenol (IPA), whereas that produced by epinephrine (E) was inhibited by phenoxybenzamine but not by propranolol. We conclude that in the dosages of the drugs used, catecholamine-stimulated sodium influx through isolated frog skin is blocked by propranolol and phenoxybenzamine while chloride outflux is blocked by phenoxybenzamine but not by propranolol.
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