Abstract
Summary
Cross-reactions were obtained between HSV type 1 and type 2 rabbit antisera using the mixed agglutination (MA) test for detection of HSV surface antigen on infected cells. Monotypic sera could be prepared by appropriate absorption with cells infected with the heterologous type. Using monospecific sera, HSV isolates were typed by MA. Results obtained by MA revealed solid agreement with kinetic neutralization test. A total of 96 isolates were typed and the association with the clinical situation was as might have been expected. The characteristics of surface antigen produced by HSV type 2 were found to be similar to those described in previous studies from this laboratory for HSV type 1.
We thank Mrs. Fumiko Ito for her skillful technical assistance. The cooperation of Mrs. Estelle B. Moses and Miss Mary J. Schwabel of the Erie County Virology Laboratory in providing HSV isolates is greatly appreciated. This investigation was aided by General Research Support Grant RR05400.
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