Abstract
Conclusion
In conclusion, our data obtained by intraluminal perfusion of proximal tubules with rat Ringer's containing 22Na and 3H-inulin, and with the presence of amiloride, furosemide, or ethacrynic acid in blood and not in the perfusate, can be easily explained if Na is reabsorbed via two parallel pathways: furosemide would inhibit the intracellular (active) pathway, amiloride would inhibit the intercellular (passive) pathway, and ethacrynic acid would not have any effect on either pathway.
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