Abstract
Summary
A protein kinase, which is one of the key components of a renal cyclic AMP mechanism, has been isolated, characterized, and studied with respect to its ability to generate erythropoietin (ESF) in an in vitro system. This enzyme was found to activate the renal erythropoietic factor (erythrogenin) in the presence of cyclic AMP which led to an increase in the generation of ESF from plasma. These data suggest that this renal cyclic AMP-dependent protein kinase which is present in the normal kidney plays an important role in kidney ESF production after erythropoietic stimulation.
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