Abstract
Summary
The left cervical vagi of four domestic fowl, under pentobarbital anesthesia, were subjected to direct electrical stimulation. The stimulation parameters used were 5, 10, 15, 20, 25, 30, 40, and 50 V in successive 30-min steps, with the frequency and duration maintained at 10 pulses/sec and 1 msec, respectively.
By kinetic analysis, a threshold of 13.6 V was found for H+ secretion and 13.9 V for pepsin secretion. Linear transformations of the data produced good linearity (r = + .999 and +.993) for acid and pepsin, respectively. The levels of secretion produced by vagal stimulation exceeded previously reported outputs for cholinergic stimulation, and it was shown that the gastric response to direct electrical stimulation of the vagus is dose-dependent and not all-or-none.
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