Abstract
Summary
Elevations in liver weight, liver/body weight, and microsomal protein content associated with chronic clofibrate administration in male rats were found to be dependent upon the age of the animals. Pretreatment with clofibrate significantly reduced pentobarbital and zoxazolamine sleeping times and enhanced the rates of microsomal metabolism for pentobarbital, ethylmorphine and aminopyrine. Specific activities of microsomal enzymes involved with the hy droxylation of zoxazolamine or aniline remained unaffected via chronic drug administration. The metabolism of all drug substrates were significantly increased via pretreatment with clofibrate when the results were expressed on the basis of total liver protein.
The authors thank Ayerst Laboratories for the generous supply of clofibrate (Atromid-S).
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